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Saurin lab manuscripts (click on my name to open up the article in a new page)
Allan L, Corno A, Valverde JM, Ly T, and Saurin AT. A chemical-genetic system to rapidly inhibit PP2A-B56 phosphatase. bioRxiv. (2024). https://doi.org/10.1101/2024.07.23.604754.
Coats JT, Li S, Tanaka TU, Tauro D, Sutherland C and Saurin AT. Elraglusib induces cytotoxicity via microtubule destabilisation independently of GSK3 inhibition. bioRxiv 2024. https://doi.org/10.1101/2024.07.06.602326
Foy R, Lew KX, Saurin AT. The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays. NPJ Breast Cancer. 2024 Mar 4;10(1):19. https://doi.org/10.1038/s41523-024-00624-8.
Manuscript originally posted to bioRxiv (see here)
Foy R, Crozier L., Pareri AU, Valverde JM, Park BH Ly Y and Saurin AT. Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest. Molecular Cell. 2023 Nov. 83(22) 4047-4061.E6. https://doi.org/10.1016/j.molcel.2023.10.020
Manuscript originally posted to bioRxiv (see here)
Commentary article for Foy et al (2023) in Molecular Cell: click here
Crozier L, Foy R, Adib R, Kar A, Holt JA, Pareri AU, Valverde JM, Rivera R, Weston WA, Wilson R, Regnault C, Whitfield P, Badonyi M, Bennett LG, Vernon EG, Gamble A, Marsh JA, Staples CJ, **Saurin AT, **Barr AR and **Ly T. CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Molecular Cell. 2023 Nov. 83(22) 4062-4077.E5. *joint first-authors. **co-corresponding authors
Manuscript originally posted to bioRxiv (see here)
Commentary article for Crozier et al (2023) in Molecular Cell: click here
Corno A, Cordeiro MH, Allan LA, Wei Q, Harrington E, Smith RJ and Saurin AT. A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity. EMBO J 2023 Oct. 42(20): e112630. https://doi.org/10.15252/embj.2022112630
Manuscript originally posted to bioRxiv, reviewed at Review Commons, and reviews posted on bioRxiv (see here)
Crozier L, Foy R, Mouery BL, Whitaker RH, Corno A, Spanos C, Ly T, Cook JG, and Saurin AT. CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal. EMBO J 2022 Mar 15;41(6):e108599; doi: https://doi.org/10.1101/2021.02.03.428245
Commentary article for Crozier et al (2022) in EMBO J: click here
Manuscript originally posted to bioRxiv, reviewed at Review Commons, and reviews posted on bioRxiv (see here)
Cordeiro MH, Smith RJ, Saurin AT. Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint. J Cell Biol. 2020 Dec 7;219(12):e202002020. doi: 10.1083/jcb.202002020.
Commentary article for Cordeiro et al (2020) in J Cell Biol: click here
Manuscript originally posted to bioRxiv, reviewed at Review Commons, and reviews posted on bioRxiv (see here)
Allan LA, Camacho Reis M, Ciossani G, Huis in ’t Veld P, Wohlgemuth S, Kops GJPL, Musacchio A and Saurin AT. Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. EMBO J. 2020. Mar 23:e103180. doi: 10.15252/embj.2019103180.
Commentary article for Allan et al (2020) in EMBO J: click here
Commentary article for Allan et al (2020) in J Cell Biol: click here
Manuscript originally posted to bioRxiv (see here)
Sloan RJS and Saurin A. 2019. The Enemy Within: Designing a Cell-Based Gameplay System for Cancer Education. Proceedings of CHI Play 2019, Barcelona, Spain.
Click here for the unformatted open access version
*Smith RJ, *Cordeiro MH, Davey NE, Vallardi G, Ciliberto A, Gross F and Saurin AT. PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore. 2019 Apr. Cell Reports In Press. *equal contribution
PreLights commentary article for Smith et al (2019): click here
Manuscript originally posted to bioRxiv (see here)
Cell scientist to watch – Adrian Saurin. Journal of Cell Science 2019
Vallardi G, Allan LA, Crozier L and Saurin AT. Division of labour between PP2A-B56 isoforms at the centromere and kinetochore. eLife. 2019 Mar 4;8. pii: e42619. doi: 10.7554/eLife.42619.
Manuscript originally posted to bioRxiv (see here)
Saurin AT. Kinase and Phosphatase Cross-Talk at the Kinetochore. Front Cell Dev Biol. 2018 Jun 19;6:62
Skowyra A, Allan LA, *Saurin AT, *Clarke PR. USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability. Cell Reports. 2018 Apr 17;23(3):852-865 * Co-corresponding
Gelens L and Saurin AT. Exploring the function of dynamic phosphorylation-dephosphorylation cycles. Developmental Cell. 26 March 2018, Pages 659–663
Short video description of Gelens and Saurin (2018): Click here
Gelens L, Qian J, Bollen M and Saurin AT. The Importance of Kinase-Phosphatase Integration: Lessons from Mitosis. Trends in Cell Biology. 2018 Jan. click here for unformatted open access version
Short video description of Gelens et al (2018): Click here
Smith L, Farzan R, Ali S, Buluwela L, Saurin AT, Meek DW. The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation. Sci Rep. 2017 Nov 23;7(1):16115.
Cordeiro MH, Smith RJ, Saurin AT. A fine balancing act: A delicate kinase-phosphatase equilibrium that protects against chromosomal instability and cancer. Int J Biochem Cell Biol. 2017 Nov 3.
Click here for unformatted open access version.
Vallardi G, Cordeiro MH and Saurin AT. A kinase-phosphatase network that regulates kinetochore-microtubule attachments and the SAC. Progress in Molecular and Subcellular Biology. 2017;56:457-484. Click here for unformatted open access version.
Saurin AT and Kops GJPL. Studying kinetochore kinases. Methods in Molecular Biology. 2016;1413:333-47.
Click here for unformatted open access version.
Vallardi G and Saurin AT. Mitotic kinases and phosphatases cooperate to shape the right response. Cell Cycle. 2015;14(6):795-6.
Mchedlishvili N, Jonak K, Saurin AT. Meeting report--Getting Into and Out of Mitosis. J Cell Sci. 2015 Nov 15;128(22):4035-8.
Nijenhuis W, Vallardi G, Teixeira A, *Kops GJ, *Saurin AT. Negative feedback at kinetochores underlies a responsive spindle checkpoint signal. Nature Cell Biology. 2014. Dec;16(12):1257-64.
Click here for unformatted open access version.
Mullers E, Cascales HS, Jaiswal H, Saurin AT, Lindqvist A. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle. 2014 13:17, 2733-2743
Kuijt T, Omerzu M, Saurin AT, and Kops GJPL. Conditional targeting of Mad1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma. 123(5):471-80.
Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJPL, Voest EE, Medema RH. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. PNAS. 2014. 20;111(20):7313-8.
Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A. Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the s/g2 transition. Molecular Cell. 2014 53(5); 843-853.